Description
CD36, also known as platelet glycoprotein 4, is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands. It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues. It also plays a significant role in the initiation and pathogenesis of chronic inflammatory diseases such as Alzheimer s disease and atherosclerosis. It is an integral membrane protein primarily serving as receptors for thrombospondin and collagen and by the erythrocytes infected with the human malaria parasite. Recombinant mouse CD36, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques